As I was stirring a pot of bubbling broth, the robust aromas filled my kitchen and transported me straight to the heart of Italy. This Italian Penicillin Soup isn’t just any chicken soup—it’s a hearty embrace in a bowl, crafted to warm you from the inside out. With its rich, silky texture and infusion of zesty lemon and creamy Parmesan, this comfort food is perfect for chilly evenings or when you need a little extra love during cold and flu season. Packed with tender chicken, vibrant vegetables, and nourishing pasta, it offers not only a delightful meal but also a much-needed hug in a bowl. Plus, it’s a gluten-free option with simple substitutions! Aren’t you curious to discover how to bring this bowl of comfort to your table?

Why is Italian Penicillin Soup so comforting?

Warmth: This soup is like a cozy blanket, enveloping you in soothing flavors and aromas that evoke memories of home-cooked meals.

High Protein: Each hearty bowl is loaded with tender chicken, providing a satisfying, protein-packed experience that keeps you feeling full and energized.

Gluten-Free Options: Easily customize it to fit your dietary needs by swapping out the pasta for gluten-free alternatives or even using cannellini beans for a veggie twist.

Versatility: This recipe invites creativity! Feel free to toss in seasonal vegetables or experiment with different leafy greens to make it uniquely yours.

Flavor Explosion: With bright lemon and savory Parmesan, every spoonful offers a burst of balanced flavors that dance on your palate, truly a taste of Italy.

Crowd-Pleasing: Whether it’s a chilly day or a family gathering, this soup is sure to be a hit, just like my Tortellini Soup or Wild Rice Soup.

Italian Penicillin Soup Ingredients

For the Broth
Olive oil – Adds richness and flavor.
Substitution: Can use vegetable oil for a lighter option.
Butter – Contributes creaminess and depth to the broth.
Substitution: Use ghee for a dairy-free alternative.
Onion – Enhances sweetness and aromatic depth.
Preparation: Use yellow or white onion, diced.
Garlic – Offers a fragrant kick and depth.
Preparation: Mince finely for even distribution.
Chicken broth (low-sodium) – Forms the savory base of the soup.
Substitution: Vegetable broth for a vegetarian version.
For the Soup Base
Boneless skinless chicken thighs (or breasts) – The main protein source, adds heartiness.
Substitution: Can use leftover chicken as a shortcut; shred before adding to soup.
Italian seasoning – Blends flavors that define Italian cuisine.
Preparation: Dried mix; can substitute with fresh herbs like basil or oregano.
Red pepper flakes (optional) – Adds a hint of heat.
Substitution: Adjust to taste, omit for a milder flavor.
For the Vegetables
Carrots – Adds sweetness and texture to soup.
Preparation: Slice into rounds; can substitute with parsnips for a unique flavor.
Celery – Provides crunch and a classic soup flavor.
Substitution: Leeks can be used for a milder taste.
Fresh baby spinach (or chopped kale or escarole) – Provides vibrant color and nutrients.
Substitution: Any leafy green that wilts well can be used.
For the Pasta and Finish
Ditalini pasta (uncooked, or orzo) – Gives a comforting, filling texture.
Substitution: Any small pasta shape will work, including broken spaghetti.
Lemon juice – Brightens and balances flavors.
Preparation: Freshly squeezed is best for optimal flavor.
Parmesan cheese (freshly grated) – Adds creaminess and a savory finish.
Substitution: Use Pecorino Romano for a stronger flavor.
Salt and freshly ground black pepper – Essential for seasoning to taste.
No substitutions required.
Fresh parsley (chopped, or basil, for garnish) – Adds freshness and visual appeal.
Optional: Enjoy as a final touch for flavor and presentation.

Step‑by‑Step Instructions for Italian Penicillin Soup

Step 1: Heat the Base
In a large pot, heat 2 tablespoons of olive oil and 1 tablespoon of butter over medium heat. Allow the fats to melt and shimmer, which will take about 2 minutes. This combination creates a rich base for your Italian Penicillin Soup, so it should look glossy.

Step 2: Sauté Vegetables
Add 1 diced onion, 2 sliced carrots, and 2 chopped celery stalks to the pot. Stir occasionally for 5-6 minutes until the vegetables are softened and the onion turns translucent. Enjoy the fragrant aroma as it fills your kitchen, signaling the start of your comforting soup.

Step 3: Add Garlic
Stir in 2 minced garlic cloves and cook for an additional 30 seconds, allowing the garlic to become fragrant but not browned. This step infuses the Italian Penicillin Soup with a delightful warmth. You’ll know it’s ready when the garlic releases its aroma, adding depth to your broth.

Step 4: Incorporate Broth and Chicken
Pour in 6 cups of low-sodium chicken broth along with 1 pound of boneless chicken thighs. Sprinkle in 1 tablespoon of Italian seasoning and optional red pepper flakes. Increase the heat to bring the mixture to a boil, watching as it bubbles and comes to life, which should take about 5 minutes.

Step 5: Simmer the Soup
Once boiling, reduce the heat to a low simmer and cover the pot. Let it cook for 20 minutes, allowing the chicken to become tender and flavorful. The broth will deepen, and you’ll see the vibrant colors of the vegetables shining through, indicating a comforting base is forming.

Step 6: Blend for Texture
Remove the chicken from the pot and set it aside to cool slightly. Use a slotted spoon to take half of the vegetables and broth, and blend them until smooth. Return this purée to the pot, enhancing the soup’s texture while retaining the fresh ingredients of the Italian Penicillin Soup.

Step 7: Shred the Chicken
Once cool enough to handle, shred the chicken using two forks and return it to the pot. Stir well to combine everything, and admire how the chunks of chicken mingle with the soup’s vibrant base, adding heartiness to your comforting dish.

Step 8: Cook the Pasta
Add 1 cup of ditalini pasta or orzo to the pot. Cook for an additional 8-10 minutes until the pasta is al dente. Stir occasionally to prevent it from sticking. You’ll know it’s done when the pasta is tender yet firm to the bite, contributing to the soup’s comforting nature.

Step 9: Finish with Flavor
Stir in 2 tablespoons of freshly squeezed lemon juice, ½ cup of grated Parmesan cheese, and 2 cups of baby spinach. Adjust seasoning with salt and freshly ground black pepper. The soup should joyfully bubble as it combines all the flavors, creating a heartwarming finish to your lovely Italian Penicillin Soup.

Step 10: Serve and Garnish
Ladle the soup into bowls and garnish with chopped parsley or basil, along with extra Parmesan if desired. The soup should look vibrant and inviting, ready to provide warmth and comfort. Serve hot, and enjoy a bowl of what feels like a hug on a chilly day!

Expert Tips for Italian Penicillin Soup

Mind the Texture: Blend only half of the vegetables to maintain a hearty bite in your Italian Penicillin Soup. Too much blending can make it too smooth!
Perfect Pasta: Undercook the pasta slightly if you plan to store leftovers. This way, it won’t become mushy when reheating.
Layered Flavor: For added depth, sauté your garlic just until fragrant and avoid browning; this helps keep the robust flavor clean and fresh.
Creative Storage: Freeze the soup without added pasta to preserve its texture. Cook fresh pasta when ready to enjoy your bowl of comfort.
Season to Taste: Adjust seasoning generously after adding the lemon juice and Parmesan, as these ingredients can enhance the overall flavor significantly.

Storage Tips for Italian Penicillin Soup

Fridge: Store leftover Italian Penicillin Soup in airtight containers for up to 4 days. Make sure to cool the soup completely before sealing to avoid condensation.

Freezer: For longer storage, freeze the soup without pasta in suitable freezer-safe containers for up to 3 months. This helps maintain the texture and flavor upon reheating.

Reheating: When ready to enjoy, thaw overnight in the fridge. Reheat gently on the stove until warm, and add freshly cooked pasta to maintain its delightful consistency.

Enjoy Later: If you plan to make the soup ahead of time, consider undercooking the pasta before freezing to prevent it from becoming mushy when you reheat the meal later.

Make Ahead Options

This Italian Penicillin Soup is perfect for meal prep, allowing you to enjoy a comforting dish even on your busiest days! You can prepare the soup base (steps 1-6) up to 24 hours in advance and refrigerate it in an airtight container. To maintain the best quality, wait to add the pasta until you’re ready to serve, as it can become mushy if left in the broth. When you’re ready to enjoy, simply reheat the soup on the stove, add 1 cup of ditalini pasta, and cook for 8-10 minutes until tender. You’ll have a warm, hearty meal ready with minimal effort!

Variations & Substitutions for Italian Penicillin Soup

Embrace the magic of customization with these friendly twists that will make your Italian Penicillin Soup even more delightful!

Dairy-Free: Switch the butter for coconut oil and use nutritional yeast instead of Parmesan for a creamy finish.
Vegetarian Delight: Replace chicken with cannellini beans and sub in vegetable broth for a nourishing vegetarian option. It’s just as satisfying and truly flavorful!
Extra Veggies: Add seasonal vegetables like zucchini or peas for additional texture and color. These vibrant ingredients will brighten up your soup with fresh flavors.
Gluten-Free Pasta: Opt for gluten-free pasta or even spiralized zucchini instead of ditalini for a lighter, healthy alternative that suits everyone.
Garnish Varieties: Instead of parsley, try fresh basil or a sprinkle of chives for a unique twist in flavor and presentation. These herbs will elevate the aroma beautifully!
Short on Time: Use rotisserie chicken to cut down on prep time—just shred it and add it directly to the soup for a quick fix. Your comfort meal will be ready in no time!
Heat Lovers: If you crave a spice kick, add diced jalapeños or increase the red pepper flakes. Let those flavors ignite your taste buds!
Old-World Richness: Incorporate a splash of white wine to the broth for a subtle depth and sophistication that transports you to a rustic Italian kitchen.

Feel free to explore these variations, much like how we’ve crafted beloved recipes like Chunky Beef Soul or Beef Barley Soup. Let’s create your own personalized bowl of warmth together!

What to Serve with Italian Penicillin Soup

As you prepare to indulge in this inviting bowl of warmth, think about the delightful sides that will complement its rich flavors and wholesome ingredients.

Crusty Bread: Freshly baked, crusty bread is perfect for soaking up every last drop of that silky broth, adding a satisfying crunch to your meal.
Simple Green Salad: A crisp salad with lemon vinaigrette provides a refreshing contrast to the hearty soup, enhancing the overall dining experience.
Garlic Bread: Golden, buttery garlic bread brings an extra layer of flavor and comfort, making each bite a cozy, indulgent experience.
Roasted Vegetables: Caramelized seasonal vegetables bring warmth and natural sweetness, providing a deliciously vibrant counterpart to the soup.
Parmesan Crisps: Crunchy parmesan crisps add a delightful texture and a savory touch, amplifying the soup’s cheesy notes.
White Wine: A light, crisp white wine such as Sauvignon Blanc complements the lemony zest and balances the comforting richness of the soup.
Fruit Sorbet: For dessert, a scoop of refreshing fruit sorbet acts as a light, palate-cleansing finish that beautifully contrasts the hearty nature of the soup.
Herb Olive Oil: Drizzling herb-infused olive oil over the soup can elevate its flavors, making it a delightful way to enhance the Italian experience.

Each pairing adds a unique touch, turning your meal into a culinary celebration.

Italian Penicillin Soup Recipe FAQs

What type of chicken should I use for Italian Penicillin Soup?
I recommend using boneless skinless chicken thighs for their tenderness and flavor, but you can also opt for chicken breasts if you prefer. If you have leftover cooked chicken on hand, you can shred it and stir it in at the end for a quick and easy shortcut!

How should I store leftover Italian Penicillin Soup?
Store your leftover soup in airtight containers in the refrigerator for up to 4 days. Make sure to let the soup cool entirely before sealing the container. This helps to maintain the flavor and prevent any condensation, which can make the soup watery.

Can I freeze Italian Penicillin Soup?
Absolutely! You can freeze the soup in suitable freezer-safe containers without the pasta for up to 3 months. When you’re ready to enjoy it, thaw it in the fridge overnight and reheat on the stove. Cook fresh pasta separately to add just before serving for the best texture!

What if my soup is too thick?
If you find that your Italian Penicillin Soup is thicker than you like, simply add extra chicken broth or water until you reach your desired consistency. Stir well and let it heat through to ensure everything is combined beautifully. Adjust seasoning if necessary after adding more liquid.

Can I make Italian Penicillin Soup gluten-free?
Yes, you can make this soup gluten-free by substituting the pasta with gluten-free pasta or using cannellini beans for added protein. Make sure to also use a gluten-free chicken broth or vegetable broth to keep the entire dish compliant with gluten-free diets.

How do I know if my vegetables are ripe for the soup?
Select fresh vegetables for the best flavor. Look for firm carrots and celery with no dark spots or soft spots. Onions should be dry and firm, while spinach or kale should be vibrant and free of wilting. Using fresh produce will elevate your Italian Penicillin Soup!