In a large bowl, combine the buttermilk, garlic powder, onion powder, paprika, salt, and black pepper. Add the chicken breasts, ensuring they are fully submerged. Cover and refrigerate for at least 2 hours, or overnight for best results.
Preheat your oven to 400°F (200°C). Line a baking sheet with parchment paper.
In a shallow dish, mix together the flour, Parmesan cheese, and dried Italian herbs.
Remove the chicken from the buttermilk marinade, allowing excess liquid to drip off. Dredge each piece in the flour mixture, pressing lightly to ensure an even coating.
Place the coated chicken breasts on the prepared baking sheet. Drizzle the melted butter over the top of the chicken.
Bake in the preheated oven for 25-30 minutes, or until the chicken is cooked through and golden brown. An internal temperature of 165°F (75°C) is recommended.
Let the chicken rest for 5 minutes before slicing and serving.